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The multiple sclerosis (MS) drugs as a potential treatment of ARDS in COVID-19 patients.
Kloc, Malgorzata; Ghobrial, Rafik M.
Mult Scler Relat Disord ; 45: 102437, 2020 Oct.
Article in English | MEDLINE | ID: covidwho-688895

ABSTRACT

We encourage studies on the effectiveness of multiple sclerosis drugs for the treatment of ARDS in COVID-19 infection. These drugs, through the inhibition of the RhoA/actin-dependent expression of virus receptors in the macrophages and macrophage recruitment to the lungs, have the potential to inhibit cytokine storm of lung macrophages, reduce or eliminate ARDS and improve the outcome of COVID-19 infection.


Subject(s)
Coronavirus Infections/drug therapy , Enzyme Inhibitors/therapeutic use , Pneumonia, Viral/drug therapy , Respiratory Distress Syndrome/drug therapy , rhoA GTP-Binding Protein/antagonists & inhibitors , Azetidines/therapeutic use , Benzyl Compounds/therapeutic use , Betacoronavirus/drug effects , COVID-19 , Coronavirus Infections/complications , Fingolimod Hydrochloride/therapeutic use , Humans , Multiple Sclerosis/drug therapy , Pandemics , Pneumonia, Viral/complications , Respiratory Distress Syndrome/virology , SARS-CoV-2 , COVID-19 Drug Treatment
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